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KMID : 0854720070270040268
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Korean Journal of Asthma, Allergy and Clinical Immunology
2007 Volume.27 No. 4 p.268 ~ p.272
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A Case of Melkersson-Rosenthal Syndrome Presented With Periocular Edema
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Kim Tae-Wan
Kwon Jae-Woo
Yang Min-Suk
Lee So-Hee
Lee Sang-Min
Kim Se-Hoon
Kwon Hyouk-Soo
Lee Hye-Seung
Park Chang-Han
Park Heung-Woo
Kim Sun-Sin
Chang Yoon-Seok
Cho Sang-Heon
Min Kyung-Up
Kim You-Young
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Abstract
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Melkersson-Rosenthal syndrome (MRS) is a rare non-caseating granulomatous disease of unknown cause that is characterized by a triad of facial edema, facial palsy and furrowed tongue. Although most reported cases of MRS involve swelling of the perioral area, it rarely involves the periocular area. We report a case of MRS involving the periocular area for the first time in Korea. A 60-year-old man presented with recurrent orofacial swelling and facial palsy. Left facial palsy was developed one year ago. Recurrent swelling around the right orbital area and eyelid developed 6 months ago. Physical examination revealed a diffuse and firm edema of the face including the eyelids, periorbital region, and cheeks without erythema, tenderness or pitting. Upon neurologic examination, the left-sided facial palsy of peripheral nerve type was noted without abnormalities in taste sense or lacrimation. Biopsy performed from edematous cutaneous lesion revealed marked dermal edema with perivascular lymphocytic infiltration, telangiectasis and a few granulomatoid histiocytic collection, which was consistent with MRS. The patient was treated with oral antihistamines and corticosteroids without clinical improvement. Physicians should consider the possibility of MRS in the presence of any chronic facial swelling and recurrent peripheral facial palsy.
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KEYWORD
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Melkersson-Rosenthal syndrome, Orofacial edema
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